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Research Articles

Determinants of Outcomes for Acute Myeloid Leukemia Patients Treated in a Community-Based Specialized Versus Non-Specialized Hospital Setting
October 09, 2024 BST
Determinants of Outcomes for Acute Myeloid Leukemia Patients Treated in a Community-Based Specialized Versus Non-Specialized Hospital Setting
Minoo BattiwallaJu-Hsien ChaoTonya CoxJose Carlos CruzWilliam B. DonnellanAlireza EghtedarSuman KambhampatiShahbaz MalikMichael B. MarisMarcello RottaFrank T. SlovickAravind RamakrishnanVikas BhushanLindsay SearsCasey MartinJared HolderAngela JunglenNavneet MajhailCharles F. LeMaistre

Most cancer patients receive care in the community, yet few studies have evaluated the effectiveness of clinical programs outside of academic or National Cancer Institute (NCI)-designated cancer centers.

Prophylactic Cranial Irradiation prior to HCT for Acute Lymphoblastic Leukemia: To Boost or Not To Boost
October 07, 2024 BST
Prophylactic Cranial Irradiation prior to HCT for Acute Lymphoblastic Leukemia: To Boost or Not To Boost
Khalid HalahlehMohammad S. MakosehAyat M. TaqashFawzi AbuhijlaLubna S. GhatashehRozan B. Al FarLina M. WahbehIsra F. MuradiAbdelatif M. AlmousaRamiz A. Abu-HijlihHasan Hashem

Total body irradiation (TBI) with or without cranial radiation boost (CRB) is an integral component of conditioning prior to allogeneic hematopoietic cell transplantation (allo-HCT) in acute lymphoblastic leukemia (ALL).

The EMMY longitudinal, cohort study: real-world data to describe multiple myeloma management and outcomes as more therapeutic options emerge
July 23, 2024 BST
The EMMY longitudinal, cohort study: real-world data to describe multiple myeloma management and outcomes as more therapeutic options emerge
Olivier DecauxRonan GarlantézecKarim Belhadj-MerzougMargaret MacroLaurent FrenzelAurore PerrotPhilippe MoreauBruno RoyerDenis CaillotXavier LeleuMohamad MohtyLionel KarlinPierre FeugierSophie RigaudeauJean FontanCécile SonntagLaure VincentThomas ChalopinHerve Avet LoiseauZakaria MaaroufLouni ChanazNathalie TexierCyrille Hulin

Multiple myeloma remains incurable, and management involves cycles of treatment response, disease relapse, and further therapy. Thus, the EMMY study was designed to annually assess the therapeutic management of MM.

Outcomes of Autologous stem cell transplantation in patients with primary refractory Diffuse Large B-cell lymphoma who demonstrate chemosensitivity to salvage chemotherapy
April 10, 2024 BST
Outcomes of Autologous stem cell transplantation in patients with primary refractory Diffuse Large B-cell lymphoma who demonstrate chemosensitivity to salvage chemotherapy
M Shahzad RaufIrfan MaghfoorMuhammad AseafanKhadijah Al ShankatiAli M. AlhanashFaateh SohailTusneem A. M. ElhassanSaad Akhtar

Our study suggests that in patients with primary refractory DLBCL without initial progressive disease after frontline R-CHOP, the depth of response to SC before HDC–ASCT is predictive of relapse.

March 04, 2024 BST
Sinus bradycardia as a rare adverse event in patients receiving cyclosporine A after allogeneic hematopoietic stem cell transplantation.
Magdalena KarasekMaciej MajcherekBartłomiej KuszczakAgnieszka SzeremetOlga ChyrkoTomasz WróbelAnna Czyż

Our single-center experience can help prompt diagnosis and therapeutic intervention in daily clinical practice.

March 03, 2024 BST
Walking ability in adults with severe hemophilia: A cross-sectional study
Malika JhandaiDimple ChoudhrySudhir Kumar AtriPankaj BhardwajKusum Yadav

The primary symptom of severe hemophilia is spontaneous and recurrent bleeding into joints, muscles, and soft tissues. Unpreventable bleeding may cause arthropathy, chronic discomfort, and muscular atrophy.

Early de-escalation of antibiotic therapy in hospitalized cellular therapy adult patients with febrile neutropenia
February 22, 2024 BST
Early de-escalation of antibiotic therapy in hospitalized cellular therapy adult patients with febrile neutropenia
Mariana LucenaKelly J GaffneyTheresa UrbanCatherine ForbesPavithra SrinivasNavneet S MajhailEric CoberSherif B MossadLisa RybickiBetty K Hamilton

Antibiotic DE in neutropenic HCT or CAR T-cell therapy patients treated with broad-spectrum antibiotics for at least three days appears to be a safe and effective practice.

Supportive Care of Hematopoietic Stem Cell Donors
February 20, 2024 BST
Supportive Care of Hematopoietic Stem Cell Donors
Wolfgang P RennertJenna Smith MKatie A CormierAnne E Austin

Post-procedure care focuses on pain management, blood cell recovery, and the psychological support necessary to regain a high-quality-of-life existence. Hematopoietic stem donors are giving part of themselves, saving another’s life.

Human herpesvirus type 6 reactivation after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide and antithymocyte globulin: risk factors and clinical impact
February 02, 2024 BST
Human herpesvirus type 6 reactivation after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide and antithymocyte globulin: risk factors and clinical impact
Annalisa PaviglianitiTânia MaiaJoël-Meyer GozlanEolia BrissotFlorent MalardAnne BanetZoé Van de WyngaertTounes LedraaRamdane BelhocineSimona SestiliAntoine CapesNicolas StockerAgnès BonninAnne VekhoffOllivier LegrandMohamad MohtyRémy Duléry

Patients with a low ALC on day +30 face a higher risk of HHV6 reactivation and may require careful monitoring.

Tolerability of Daratumumab Amongst Asian Patients with Plasma Cell Dyscrasias – A Single Centre Experience.
January 16, 2024 BST
Tolerability of Daratumumab Amongst Asian Patients with Plasma Cell Dyscrasias – A Single Centre Experience.
Allison C. Y. TsoSamuel S. Y. WangChristian A. GallardoDheepa ChristopherKiat Hoe Ong

In conclusion, daratumumab is tolerable amongst Asian patients, including the elderly, and patients with severe renal impairment and chronic lung diseases.

January 05, 2024 BST
Incidence and Risk of Secondary Malignancy in Patients with Waldenström Macroglobulinemia: A Population-Based Analysis
Mohammad Ebad Ur RehmanMaha HameedZunairah ShahOmer S AshrufRabia AliFatima FarazJawad BasitIsrar KhanFaizan FazalAhmad IftikharAbdulqadir J NashwanMuhammad Salman FaisalFaiz Anwer

The risk of SM development may be due to genetic predisposition, immune dysregulation, or treatment-induced immune suppression.

September 08, 2023 BST
Racial Disparities in Plasma Cell Leukemia Outcomes Among Hospitalized Patients in the United States
Cindy WuDeepa DongarwarSamer Al Hadidi

Plasma cell leukemia (PCL) is a rare, aggressive subtype of multiple myeloma (MM) with a poor prognosis. We deal with racial disparities that affect MM patients.